منابع مشابه
Lamotrigine-induced Neutropenia Followed by Drug Eruption: A Case Report
A 55-year-old female with no physical problems was initially hospitalized for psychotic mania but soon discharged. A month later she was rehospitalized for bipolar depression and treated with lamotrigine (25 mg/day), olanzapine (10 mg/day), and lorazepam (0.5 mg/day). On day 22, lamotrigine was stopped because of neutropenia. On the same day, the patient developed skin rashes with pruritus, whi...
متن کاملReview: Drug-induced neutropenia--pathophysiology, clinical features, and management.
Drug therapy plays a significant role in causing neutropenia. The neutropenia may be immune mediated or due to direct inhibition of the bone marrow precursors. Recently, due to wide use of chemotherapy, febrile neutropenia has become a common and devastating problem. Neutropenia predisposes to many bacterial and fungal infections with organisms including gram negative bacilli such as E. coli, K...
متن کاملCongenital neutropenia.
Congenital neutropenia comprises a variety of genetically heterogeneous phenotypic traits. Molecular elucidation of the underlying genetic defects has yielded important insights into the physiology of neutrophil differentiation and function. Non-syndromic variants of congenital neutropenia are caused by mutations in ELA2, HAX1, GFI1, or WAS. Syndromic variants of congenital neutropenia may be d...
متن کاملCyclic neutropenia.
Cyclic neutropenia is a rare hematologic disorder, characterized by repetitive episodes of fever, mouth ulcers, and infections attributable to recurrent severe neutropenia. Fluctuations in blood cells are due to oscillatory production of cells by the bone marrow. Recent genetic, molecular, and cellular studies have shown that autosomal-dominant cyclic neutropenia and sporadic cases of this dise...
متن کامل[Autoimmune neutropenia].
There have been several new developments in the field of autoimmune neutropenia over the past decade. Neutropenia caused by antibodies directed against granulocyte precursor cells, the oligoclonal nature of antineutrophil antibodies, and the expanding knowledge of neutrophil antigens, particularly in relationship to autoantibodies, are exciting new areas of investigation. Knowledge has also bee...
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ژورنال
عنوان ژورنال: BMJ
سال: 1970
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.5705.364-c